Gene/Protein role prediction in adipocyte phenotypes

Our approach helps to explore/estimate the role of a given protein/gene in shaping the two main adipocyte phenotypes (BROWN and WHITE, or both as a LINKER). In the study by Tóth et. al. 2021 we generated a BROWN, WHITE and LINKER gene/protein network containing theoretically all participants in forming the adipocyte phenotype. Nodes in the network represent a gene/protein.

The AdipoNET platform facilitates the easy use of our network position based data in practice. The position of the nodes was evaluated in two ways: calculating the betweenness centrality value to measure others’ dependence on a given node, and therefore as a measure of potential control, and the number of bridges score for identifying the number of linked functional units (clusters/genes/proteins) in the network. The colour of the bar graph shows which adipocyte phenotype the gene/protein may potentially be involved in shaping. The maximum and minimum values are the most and the least scores identified by network analysis.

The network was generated by the Cytoscape tool based on 3705 genes/proteins and their protein interaction data from the STRING database. Visual representation can be found below:

Authors:

• B Tóth, B., Barta, Z., Barta, Á. B., & Fésüs, L. (2021). Regulatory modules of human thermogenic adipocytes: functional genomics of large cohort and Meta-analysis derived marker-genes. BMC genomics, 22(1), 1-21.

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